Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gustchina, A.; Weber, I.T.; Wlodawer, A.
    Molecular modeling of the HIV-2 protease (1991), Adv. Exp. Med. Biol., 306, 549-553.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.23.47 medicine potential target for chemotherapy of virus infection and associated diseases, essential for maturation of infectious virions, development of drugs against the protease should be effective against HIV-2 Human immunodeficiency virus 2

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.23.47 cloned and sequenced Human immunodeficiency virus 2

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.23.47 crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398 Human immunodeficiency virus 2

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.47 acetyl-pepstatin common inhibitor of aspartic proteases Human immunodeficiency virus 2
3.4.23.47 H-261 renin inhibitor Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.47 GAG precursor protein of HIV-2 + H2O Human immunodeficiency virus 2
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.47 Human immunodeficiency virus 2
-
 human immunodeficiency virus type 2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.47 GAG precursor protein of HIV-2 + H2O
-
 Human immunodeficiency virus 2 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.23.47 dimer symmetrical dimer of 2 subunits Human immunodeficiency virus 2